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Could circulating tumour DNA in the blood help us identify those patients that require post operative chemotherapy?

Research Scientist: Claire Swift & Monee Shamsher. Dates: September 2016 to August 2018. Final cost: £177,128.

Project summary 

Many breast cancers are currently treated with surgery followed by chemotherapy. One of the biggest research challenges is to identify those patients who will, or will not, benefit from post-operative chemotherapy. It is possible that some patients would not relapse even without chemotherapy and similarly some might relapse even following chemotherapy. This pilot study has been completed in The Ralph Lauren Centre for Breast Cancer Research. The long term aim of this research, alongside other studies including grant 6 and c-TRAK, is to build the data required to help support the case for these specialised blood tests being developed in Matthew Beaney’s project to become the standard way of detecting relapse and confidently being able to identify patients that do not need chemotherapy. 

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